Bryce and His Family Look to the Ross Eye Institute’s “Dr. Jack”

The below article was originally posted on medicine.buffalo.edu.


Bryce Stone’s struggles with sight began when he was just a preschooler. Familiar with the signs of vision loss because of a blind family member, Susan and Daniel Stone wanted to get the best diagnosis, treatment and support possible for their young son. They found John M. (Jack) Sullivan, MD, PhD, professor of ophthalmology in the Jacobs School of Medicine and Biomedical Sciences, and staff physician at the VA Western New York Healthcare System.


Sullivan focuses his lab research on development of gene-based therapeutics for retinal and macular degeneration. Through genetic testing, he diagnosed Bryce with retinitis pigmentosa (RP), a group of rare genetic disorders that involve a loss of cells in the retina, the light-sensitive tissue that lines the back of the eye. Symptoms include difficulty seeing at night and a loss of peripheral vision.


Eventually, most individuals with RP will lose their sight.


At age 11, Bryce is legally blind and preparing to live without vision.


“I have a cane now, and I’m learning how to read braille,” he explains. “I use a sighted guide, too, where I hold onto someone’s elbow to find my way.”


Bryce and his family are receiving support from several community resources, including the Olmsted Center for Sight and the Chautauqua Blind Association.


“Those doors all opened up because of Dr. Jack,” Dan Stone says.


Despite his vision loss, Bryce is very active. “I like to fish, and my dad and I play catch by using glow sticks so I can see the ball. I have braille playing cards and a magnifier, too.”


Bryce and his parents are hopeful that future medical discoveries and advances in technology may someday lead to a therapy or cure that restores his sight. That’s Sullivan’s vision, too.


He is using the latest advances in gene-based therapeutics to develop promising new approaches to treating retinal and macular degeneration. To accomplish this, he and his team are developing therapies that target and suppress (shut down) genes that stress retinal cells and cause them to degenerate. The molecular agents Sullivan is developing (ribozymes or RNAi), may also be used to alter the expression (functioning) of normal genes in order to slow down the progression of age-related retinal and macular degeneration.


In a further development, Sullivan and his team have created and are currently testing an RNA drug-discovery technology platform that has the potential to significantly accelerate gene-based therapeutics by more rapidly and accurately identifying and testing viable drug targets.


Because the promise of Sullivan’s research is so compelling, patients and families affected by these diseases are offering support. UB alumnus Roberta Stevens and her husband, George, have committed $1 million in a bequest gift to support the Department of Ophthalmology and research into age-related macular degeneration (AMD). Aleksandra Thon, whose late father suffered from AMD, has pledged $76,000 to establish the LMA Thon Endowment with the Foundation of Jewish Philanthropies to support research at UB, including Sullivan’s.


Recently, Thon met Bryce and decided to provide additional philanthropic support to fund sight-assisting equipment for him: OrCam Myeyes2 and iPhone supported by Alek.



“My father lost his sight due to age-related macular degeneration,” Thon says. “As his primary caregiver, I watched this condition deprive him of his vision and independence. That’s why I support macular degeneration research at UB, and why, in my father’s memory and honor, I wanted to help Bryce and his family.”


The research described above is supported, in part, by a VA Merit Review award from the U.S. Department of Veterans Affairs, and a National Eye Institute award.

August 28, 2026
Driving at night, walking through poorly lit spaces, or adjusting to darkness can become more difficult when your vision changes. Night vision problems , also called nyctalopia or night blindness , make it hard to see clearly in low light and may make everyday activities less comfortable or safe. At Ross Eye Institute at UBMD , our eye care specialists evaluate changes in night vision to identify the cause and recommend customized treatment options. Understanding why night vision changes occur can help you take the right steps to protect your eye health. Night vision problems occur when the eyes have difficulty seeing clearly in dim or dim-light environments. Some people notice symptoms gradually, while others experience a sudden change in their night vision. Common signs of night vision problems include: Difficulty driving at night Increased sensitivity to headlights and bright lights Trouble seeing in dark rooms Difficulty adjusting when switching from bright to dark environments Seeing halos or glare around lights Blurred or reduced vision in low illumination conditions Difficulty recognizing objects or people in dim lighting Occasional difficulty seeing at night may be normal, but persistent or worsening symptoms should be evaluated by an eye care professional. What Causes Poor Night Vision? Several eye conditions and vision changes add to poor night vision . A common cause is an outdated glasses or contact lens prescription. Refractive conditions like nearsightedness, farsightedness, and astigmatism can make nighttime vision especially challenging. Other possible causes include: Cataracts: Clouding of the eye’s natural lens can cause glare, halos, and reduced contrast, particularly at night. Glaucoma: Changes associated with glaucoma can affect vision and may make navigating low-light environments more difficult. Retina disorders: Diseases affecting the retina can interfere with the eye’s ability to function in low light. Dry eye disease: An unstable tear film may contribute to variable vision, glare, and discomfort. Certain medications or health conditions: Some medications and medical conditions may affect how the eyes adapt to darkness. Because night vision problems have many causes, a comprehensive eye exam is important to determine what affects your vision. When Should You Have Your Eyes Examined? If you regularly struggle with night driving , have increased glare from headlights, or notice changes in your vision in dark environments, schedule an eye exam. Also seek evaluation if symptoms develop suddenly or come with other vision changes. Your eye care provider may evaluate your visual acuity, prescription, eye health, and other structures of the eye to determine the source of your symptoms. Improving Your Night Vision Treatment for night vision problems depends on the underlying cause. Updating your prescription may improve vision for patients with refractive errors, while conditions such as cataracts or other eye diseases may require additional treatment.  At Ross Eye Institute at UBMD, we provide comprehensive eye care focused on identifying the cause of vision changes and helping patients preserve clear, healthy vision. If nighttime glare, difficulty seeing in the dark, or other night vision problems are affecting your daily life, schedule an eye exam to learn more about your options.
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Dry, irritated eyes can make everyday activities such as uncomfortable. Artificial tears and other treatments may deliver temporary relief but do not always provide a permanent solution to the underlying cause of chronic dry eye. For many patients, the problem begins with meibomian gland dysfunction (MGD), a common condition that affects tear film quality. At Ross Eye Institute at UBMD, we use advanced technology to treat the root cause of dry eye with OptiLight® IPL (Intense Pulsed Light) and OptiPLUS™ , helping patients achieve long-lasting comfort and healthier eyes. What Is Meibomian Gland Dysfunction (MGD)? The meibomian glands are tiny oil-producing glands located along the edges of your eyelids. These glands release oils that help prevent tears from evaporating too quickly. When the glands become blocked or stop functioning properly, tears evaporate faster, leading to dry eye symptoms such as: Burning or stinging eyes Redness Blurred vision Gritty or sandy sensation Watery eyes Eye fatigue Light sensitivity MGD is a leading cause of dry eye disease and frequently worsens over time without treatment. What Is OptiLight® IPL? OptiLight® is an FDA-approved Intense Pulsed Light (IPL) treatment specifically tailored to manage dry eye disease associated with meibomian gland dysfunction. During treatment, the skin around the eyes is exposed to controlled pulses of light. These gentle pulses help reduce inflammation, improve meibomian gland function, and decrease abnormal blood vessels that contribute to chronic dry eye. Many patients notice gradual improvement after a series of treatments, with benefits including: Reduced dry eye symptoms Improved tear stability Less eyelid inflammation Greater comfort during daily activities Boosted overall eye health The procedure is non-invasive, requires little or no downtime, and usually takes a short office visit. What Is OptiPLUS™? OptiPLUS™ is often used alongside OptiLight® to deliver a more comprehensive treatment for dry eye disease. Following IPL therapy, OptiPLUS™ gently clears blockages from the meibomian glands, allowing healthy oils to flow more freely into the tear film. This combination targets both inflammation and gland obstruction, two major contributors to evaporative dry eye. Through combining these advanced technologies, patients may experience more effective and longer-lasting relief than with traditional treatments alone. Who May Benefit from IPL Dry Eye Treatment? OptiLight® and OptiPLUS™ may be recommended for patients who: Have chronic dry eye symptoms Have been diagnosed with meibomian gland dysfunction Depend on artificial tears multiple times each day Experience eyelid inflammation or redness Have not found sufficient relief from conventional treatments Spend long hours using digital devices A comprehensive eye exam lets your eye care specialist determine if these treatments suit your individual needs. What to Expect During Treatment Your provider will first evaluate your eyes and eyelids to determine the severity of your dry eye disease and meibomian gland function. During an OptiLight® session, protective shields cover the eyes while pulses of light are delivered to the treatment area. Patients often describe the sensation as a mild snapping against the skin. If OptiPLUS™ is included in your treatment plan, your provider will then gently express the meibomian glands to remove blockages and restore healthy oil flow. Most treatment plans include a series of treatments scheduled several weeks apart to get the best possible results. Find Lasting Relief from Dry Eye Living with chronic dry eye does not have to be your new normal. Advanced therapies like OptiLight® IPL and OptiPLUS™ treat the underlying causes of evaporative dry eye rather than just masking symptoms.  At Ross Eye Institute at UBMD, our experienced eye care specialists extend personalized dry eye evaluations and advanced treatment options to help restore comfort, improve tear quality, and protect your long-term eye health. If dry, irritated eyes are affecting your quality of life, schedule an appointment to learn whether OptiLight® and OptiPLUS™ are right for you.
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Red, itchy, irritated eyes can be frustrating and uncomfortable. Many people assume these symptoms are caused by allergies, but dry eye syndrome can produce similar signs. Understanding the difference between dry eye and eye allergies is important to find the right treatment and protect your long-term eye health. At Ross Eye Institute at UBMD, our specialists work hard to identify the source of their symptoms and develop specific treatment plans to improve comfort and vision. Understanding Dry Eye Dry eye occurs when the eyes don’t make sufficient tears or when they evaporate too quickly. Tears play a key part in keeping the surface of the eye lubricated, nourished, and protected. Several variables lead to dry eye syndrome, including: • Aging • Extended screen time • Certain medications • Hormonal changes • Environmental conditions such as wind or dry air • Preexisting health conditions Dry eye symptoms may include: • Burning or stinging sensations • Gritty or sandy feeling in the eyes • Blurred vision • Eye fatigue • Sensitivity to light • Excessive tearing as a response to irritation Symptoms often worsen after reading, computer use, or prolonged visual tasks, so many patients notice discomfort later in the day. Understanding Eye Allergies Allergic conjunctivitis is a reaction to environmental allergens in which the eyes become inflamed. Common triggers include pollen, dust mites, pet dander, mold, and seasonal allergens. When the eyes come into contact with an allergen, the immune system responds by sending histamines through the body that cause inflammation and irritation. Common symptoms of eye allergies include: • Intense itching • Redness • Watery eyes • Swollen eyelids • Burning sensations • Mucus discharge Unlike dry eye, allergy symptoms often occur alongside other allergy-related issues such as sneezing, nasal congestion, or a runny nose. Key Differences Between Dry Eye and Eye Allergies Although the symptoms can overlap, several important differences may help distinguish between the two conditions. Itching Is More Common with Allergies Itching is often the hallmark symptom of eye allergies. While dry eye may cause irritation or discomfort, significant itching is more likely to be associated with an allergic reaction. Dry Eye Often Causes a Gritty Feeling Many patients with dry eye describe feeling as though sand or a foreign object is trapped in their eyes. This experience is less common with allergies. Allergies Usually Produce More Tearing Eye allergies often trigger excessive watering as the body responds to allergens. Dry eye can also cause reflex tearing, yet the eyes still feel dry. Symptoms May Follow Seasonal Patterns If symptoms worsen during spring or fall allergy seasons, eye allergies may be the cause. Dry eye symptoms persist year-round and may worsen in dry environments or during lengthy screen use. When to Schedule an Eye Examination Dry eye and eye allergies can look very similar, so a professional eye examination is often the best way to determine the underlying cause. You should schedule an evaluation if you experience: • Persistent redness or irritation • Ongoing blurry vision • Eye discomfort that does not improve • Frequent tearing or dryness • Light sensitivity • Symptoms that impede daily activities An eye care professional can assess tear production, evaluate the ocular surface, and find signs of allergies or other eye conditions. Finding Relief for Your Symptoms Proper diagnosis is the primary pathway to effective treatment. Dry eye management may include artificial tears, prescription medications, habit modifications, or advanced therapies. Eye allergy treatment often focuses on avoiding triggers and using antihistamines or anti-inflammatory medications when appropriate. At Ross Eye Institute at UBMD, we provide comprehensive eye care services to help patients find relief from dry eye symptoms, eye allergies, and other vision concerns. If you are experiencing ongoing eye irritation, scheduling a thorough optical test can determine the source and restore your comfort and eye health.
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